A 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children

a 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children.

Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose.

OBJECTIVE To compare the antipyretic efficacy of an initial 30-mg/kg acetaminophen loading dose versus a 15-mg/kg maintenance dose. METHODS A double-blind, parallel-group, randomized clinical trial was conducted. A total of 121 febrile (rectal temperature between 39 degrees C and 40 degrees C) but otherwise healthy outpatients who were 4 months to 9 years of age and weighed 4 to 26 kg were as...

comparison of high loading dose versus usual dose of rectal acetaminophen in the treatment of febrile children

background: the superiority of antipyretic efficacy of high dose rectal acetaminophen is not well established yet. objectives: the present study aimed to compare the antipyretic effectiveness of high loading dose (30 mg/kg) and standard dose (15mg/kg) of rectal acetaminophen in febrile children. patients and methods: this triple blind randomized clinical trial was conducted on 76 patients aged ...

Ibuprofen was more protective against asthma morbidity than acetaminophen in asthmatic children with fever.

Patients 1879 children between 6 months and 12 years of age (median age 46 mo, 62% boys) who were being treated for asthma with a -agonist, theophylline, or inhaled steroid and had a febrile illness. Exclusion criteria were known sensitivity to acetaminophen, ibuprofen, aspirin, or any non-steroidal anti-inflammatory drug (NSAID); nasal polyps; angioedema; or bronchospastic reactivity to aspiri...

Effect on platelet reactivity from a prasugrel loading dose after a clopidogrel loading dose compared with a prasugrel loading dose alone: Transferring From Clopidogrel Loading Dose to Prasugrel Loading Dose in Acute Coronary Syndrome Patients (TRIPLET): a randomized controlled trial.

BACKGROUND Adding a prasugrel loading dose (LD) to a clopidogrel LD could be desirable because clopidogrel may fail to provide adequate levels of platelet inhibition in patients with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS The pharmacodynamic response of prasugrel 60 mg ld alone was compared with prasugrel 60 mg or 30 mg added 24 hours to clo...